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Evidence

From the sources we read every week for our concierge recommendations.

• Rhonda Patrick

  “How To Boost NAD Levels To Fight Inflammation, Improve Recovery, and Slow Aging | Dr. Charles Brenner”

  Common clinical trial dosing of NR is 500–1,000 mg/day, and NR has been safely tested up to 3 grams per day in certain populations. Most people probably shouldn't go beyond that dose due to lack of safety and efficacy data. Combining NR with other compounds Dr. Brenner notes two main compounds that NR has been combined with in clinical studies, with lackluster results. Resveratrol—he argues there's no strong use case, and points to data in peripheral artery disease where NR + resveratrol underperformed NR alone.[[22]](https://www.foundmyfitness.com/episodes/charles-brenner#bibid-doi-10-1038-s41467-024-49092-5) Pterostilbene—he warns it can raise LDL cholesterol in a dose-dependent manner and says it's not necessary for NAD boosting. Safety and cancer risk "We know from the Australian nicotinamide trials that supplementing with the classic NAD booster nicotinamide lowers cancer risk at the population level."- Charles Brenner, Ph.D.Click To Tweet The main safety concern with NR supplementation is whether you're taking material that matches what has been clinically tested—not simply a label claim on a marketplace listing. Otherwise, NR (e.g., Niagen) has been accepted by the FDA as generally recognized as safe (GRAS) for specific uses in food and supplements. It's recognized as a new dietary ingredient but is not approved as a drug to treat, prevent, or cure diseases. NR adverse event reporting is tracked under the FDA's "food" regulatory framework for dietary ingredients. Cancer risk Population-level evidence does not support the fear that NAD boosting "causes cancer." In fact, it may be cancer-preventative. Nicotinamide (another NAD precursor vitamin) has been shown in Australia to reduce non-melanoma skin cancer risk in a phase III prevention trial and precancerous lesions (actinic keratoses) in a 4-month phase II study.[[24]](https://www.foundmyfitness.com/episodes/charles-brenner#bibid-doi-10-1056-nejmoa1506197)[[25]](https://www.foundmyfitness.com/episodes/charles-brenner#bibid-doi-10-1038-jid-2011-459) Specific chemo contexts could be contraindicated, and for active cancer treatment situations, Dr. Brenner advises physician guidance rather than blanket reassurance. Practical takeaways Does everyone need to supplement with NR? Probably not (even Dr. Brenner seems to readily admit that it's not necessary for everyone). If you're healthy and active, the most compelling use case he offers is training adaptation/recovery, especially when you're pushing consistent volume or intensity. If you're dealing with chronic inflammation risk (obesity, respiratory disease, chronic stressors), NR has the strongest repeated human signal here (anti-inflammatory outcomes), but it's not a substitute for lifestyle or medical treatment.

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