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Better Sleep
Wellav8 Standard — 4.6/5

Thorne Magnesium Bisglycinate

“The gold standard in bioavailable magnesium.”

$25–35supplement

Thorne has been the practitioner's choice for decades. Their magnesium bisglycinate is chelated for maximum absorption — meaning your body actually uses it instead of flushing it. No fillers, no artificial colors, NSF Certified for Sport. This is the form that crosses the blood-brain barrier and activates GABA receptors for genuine relaxation.

Our assessment

Purity5/5
Efficacy5/5
Sourcing4/5
Value4/5
Transparency5/5

Purity & verification

Verification & Testing

NSF Certified for Sport
Third-party tested
GMP certified
Heavy metals free
No proprietary blends
COA available
View Certificate of Analysis →
Gluten-freeSoy-freeDairy-free

Why we chose it

Chelated form means 40% better absorption than magnesium oxide

NSF Certified for Sport — third-party verified purity

No fillers, no artificial colors, no unnecessary ingredients

Recommended by more functional medicine practitioners than any other brand

Key ingredients

Magnesium (as bisglycinate chelate)Hypromellose capsule

The science

Magnesium is involved in 300+ enzymatic reactions including GABA receptor activation and melatonin synthesis. Bisglycinate is bound to glycine — itself an inhibitory neurotransmitter — creating a dual calming effect. Studies show this form has 40% higher bioavailability than oxide and significantly fewer GI side effects.

Evidence

From the sources we read every week for our concierge recommendations.

  • Josh Axe

    “Magnesium Supplements: Benefits, Types, Dosage, Side Effects”

    Magnesium gluconate is a gentle, well-tolerated form of magnesium supplements made by combining magnesium with gluconic acid. It’s commonly used for gradual correction of magnesium deficiency and long-term supplementation because it’s less likely to cause digestive upset. Studies show oral magnesium gluconate can effectively raise serum magnesium levels. Like other bioavailable forms, it may help support healthy blood pressure, metabolic function and proper muscle and nerve activity. How much magnesium to take (dosage) How do you know if you should use magnesium supplements? According to the National Institutes of Health (NIH), assessing magnesium levels is difficult because most magnesium is inside cells or bones and not within the blood. This can make blood test results misleading when it comes to determining a magnesium deficiency. The most common method for assessing magnesium status is by measuring serum magnesium concentrations in the blood or by measuring concentrations in saliva and urine, but no single method is considered totally comprehensive and accurate. If you’re going to supplement, when should you take magnesium? The best time of day to take magnesium for most people is right before bed. It’s also a good idea to split doses, taking some in the morning and some at night, which can help with absorption. So, how much magnesium should you take per day? Keep in mind that magnesium needs vary on different individual factors, like your age and gender. According to the NIH, below are the recommended daily allowances (RDA) for magnesium: Infants to 6 months: 30 milligrams (mg) 7 to 12 months: 75 mg 1 to 3 years: 80 mg 4 to 8 years: 130 mg 9 to 13 years: 240 mg 14 to 18 years: 410 mg for men; 360 mg for women 19 to 30 years: 400 mg for men; 310 mg for women Adults 31 years and older: 420 mg for men; 320 mg for women Pregnant women: 350 to 360 mg Women who are breastfeeding: 310 to 320 mg How much magnesium per day is best in supplement form? This depends on the type of magnesium you take, the issue you’re attempting to improve and if you’re deficient. In some cases, high doses up to 800 to 1,800 milligrams of magnesium daily for several months are given to help treat conditions like indigestion and irregular heartbeats, but this is done under supervision from a doctor. Is it safe to take 500 milligrams of magnesium a day? Most authorities state that doses less than 350 milligrams daily are safest for most adults. In other words, the “daily upper intake level” for magnesium is 350 milligrams for anyone over 8 years old. Unless your doctor tells you otherwise, it’s best to take about 300 to 400 milligrams daily at most. For children, magnesium is safe when taken in doses of between 65 to 100 mg/day depending on age, or up to 350 mg/day for children older than 8 years. How do you choose the best magnesium supplement? When selecting a magnesium supplement, consider bioavailability, your health goals and any digestive sensitivity you may have. Forms like magnesium glycinate, taurate and amino acid chelates are generally easier on the stomach and better absorbed, while forms such as citrate and oxide may be useful for occasional constipation.

    read the source →
  • Examine.com

    “Magnesium benefits, dosage, and side effects”

    Adequate intake (AI) Reference: Institute of Medicine. Magnesium (chapter 6 of Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. The National Academies Press. 1997. DOI: 10.17226/5776) Magnesium UL The tolerable upper intake level (UL) for magnesium only includes magnesium obtained from dietary supplements and medications. Supplement doses exceeding the UL are more likely to cause adverse effects. Reference: Institute of Medicine. Magnesium (chapter 6 of Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. The National Academies Press. 1997. DOI: 10.17226/5776) Supplements Demystified: Get Our Unbiased, Evidence-Based Guide Uncover the truth about popular supplements like creatine, turmeric, garlic, zinc, melatonin, and more. Plus, we'll debunk myths surrounding multivitamins, testosterone boosters, and immune supplements. Become a savvy supplement shopper. Learn how to spot the hidden signs of low-quality products and save money by avoiding ineffective supplements. Demystify scientific studies. Develop the skill to sift through the jargon and make empowered decisions for your health. Transform your lifestyle with easy-to-apply, practical health tips. Bonus PDF: Also get Examine's Top 10 Most Popular Study Summaries over the past 12 months, covering gluten-free eating, calorie and time restricted eating, cognitive health, ashwaganda, muscle building, and more. Show me what works Examine Database: Magnesium Show Conditions Filters Expand AllCollapse All

    read the source →

How to use

Take 1–2 capsules (200–400mg elemental magnesium) 30–60 minutes before bed. Start with 1 capsule to assess tolerance. Can also be taken with meals for general support.

Who it's for

Anyone focused on better sleep, muscle recovery, or stress management. Especially if you've tried magnesium before and 'didn't feel anything' — you were probably taking the wrong form.

Get Thorne Magnesium Bisglycinate

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Related topics

SleepAnxiety StressChronic Pain

This product supports these goals.

Better Sleep
Reduce Anxiety
Muscle Recovery
Stress Relief

Wellav8 may earn a commission from products linked on this page. All products are independently selected based on our five-point standard. No brand pays for placement. These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.